Assistant Professor of Chemical Engineering
Biosensors, Interfacial Science, Biophysics, Translational Medicine, Biotechnology
OUR LABORATORY EXPLORES CUTTING-EDGE TOPICS AT THE INTERFACE OF NANOBIOTECHNOLOGY AND TRANSLATIONAL SCIENCE
We focus on characterizing the interactions of biomacromolecules and nanomaterials with biological systems, and translating scientific insights into engineered solutions to address outstanding needs in medicine and biotechnology. Key research areas include biosensor development, interfacial science, and biophysics. We also develop pharmaceutical drugs and nanomedicines for infectious disease, cancer, and immunology applications.
We have many active collaborations and exchange programs with research groups at institutions around the world, including Stanford University (USA), Cornell University (USA), the University of Pennsylvania (USA), the University of California Los Angeles (USA), Utrecht University (Netherlands), the University of Zagreb (Croatia), and Nanyang Technological University (Singapore). Selected research topics are described below.
LABEL-FREE BIOSENSORS & LIPID MEMBRANE PLATFORMS
We develop label-free biosensors for biointerfacial science applications and fundamental biophysical investigations. Particular emphasis is placed on fabricating supported lipid membrane platforms as multifunctional biointerfaces, and streamlined membrane fabrication options are being explored for translational applications such as gene delivery, microprinting, antiviral drug evaluation, and immunological testing.
PEPTIDE AND PROTEIN ENGINEERING
We design peptides and proteins with useful properties for medical and biotechnology applications. Key areas include (i) engineering membrane-active peptides that disrupt enveloped virus particles and exosomes, (ii) developing protein coatings to minimize the immunological reactivity of nanomaterials, and (iii) optimizing bioconjugation strategies for sensing and diagnostic applications.
- Yoon BK, Jeon WY, Sut TN, Cho NJ, Jackman JA. Stopping Membrane-Enveloped Viruses with Nanotechnology Strategies: Toward Antiviral Drug Development and Pandemic Preparedness. ACS Nano, In press (2020). Link
- Jackman JA, Yoon BK, Ouyang L, Ferhan AR, Kim, Majima T, Cho NJ. Biomimetic Nanomaterial Strategies for Virus Targeting: Antiviral Therapies and Vaccines. Advanced Functional Materials, In press (2020). Link
- Ferhan AR, Yoon BK, Park SH, Sut TN, Chin HK, Park JH, Jackman JA*, Cho NJ*. Solvent-Assisted Preparation of Supported Lipid Bilayers. Nature Protocols, vol. 14, pp. 2091-2118 (2019). Link
- Jackman JA, Costa VV, Park SH, Real ALCV, Park JH, Cardozo PL, Ferhan AR, Olmo IG, Poreira TP, Bambirra JL, Queiroz VF, Queiroz-Junior CM, Foureaux G, Souza DG, Ribeiro FM, Yoon BK, Wynendaele E, De Spiegeleer B, Teixeira MM, Cho NJ. Therapeutic Treatment of Zika Virus Infection Using a Brain-Penetrating Antiviral Peptide. Nature Materials, vol. 17, pp. 971-977 (2018). Link
- Jackman JA, Ferhan AR, Cho NJ. Nanoplasmonic Sensors for Biointerfacial Science. Chemical Society Reviews, vol. 46, no. 12, pp. 3615-3660 (2017). Link
Assistant Professor (Sungkyunkwan University, 2019-present)
Postdoctoral Scholar (Stanford University, 2015-2018)
Graduate Researcher (Nanyang Technological University, 2011-2015)
Graduate Researcher (Harvard-MIT, 2010-2011)
Undergraduate Researcher (Stanford University, 2008-2010)
Undergraduate Researcher (University of Florida, 2007-2008)