LIM Yong Taik | 임용택


제2종합연구동 2층 83232호실

Research Areas

Nano Medical Systems

Research Interests

Cancer immunotherapies that harness the body’s immune system to combat tumors have received extensive attention and became mainstream strategies for treating cancer. Despite promising results, some problems remain, such as the limited patient response rate and the emergence of severe immune‐related adverse effects. To overcome such obstacles, our lab is focusing on the development of new nano-pharmaceuticals that is designed, synthesized, and formulated by nano/bio/immune engineering. Our technology platform includes nanomaterials-based immunomodulatory drugs, engineered immune cells (dendritic cells, T cells, NK cells), and spatiotemporal drug delivery systems, which can induce tailored antitumor immune response and reshape immunosuppressive tumor microenvironments for enhanced cancer immunotherapy.

Adjuvants are substances added to vaccines to enhance the immunogenicity of highly purified antigens that have insufficient immunostimulatory capabilities, and have been used in human vaccines for more than 90 years. For the development of novel vaccine adjuvants in cancer immunotherapy and infectious disease, nanotechnology-based materials design has utilized key features of the size, shape, and surface molecule organization of pathogens. Inspired by the pathogens and their infection process, our lab is developing novel vaccine adjuvant materials that can tailor and boost our immune systems against various cancer and infectious disease based on the convergence of chemistry, biology, immunology, pharmacy, and engineering.

Selected Publications

Hathaichanok Phuengkham, Chanyoung Song, Soong Ho Um and Yong Taik Lim*, “Implantable Synthetic Immune Niche for Spatiotemporal Modulation of Tumor-derived Immunosuppression and Systemic Antitumor Immunity: Postoperative Immunotherapy”, Advanced Materials, 30(18),1706719 (2018). (IF=21.950)

Long Ren, and Yong Taik Lim*, “Degradation-regulatable Architectured Implantable Macroporous Scaffold for the Spatiotemporal Modulation of Immunosupressive Microenvironment and Enhanced Combination Cancer Immunotherapy”, Advanced Functional Materials, 2018 (in press). (IF=13.325)

Nak Won Kim, Sun-Young Kim, Jung Eun Lee, Yue Yin, Jong Han Lee, Su Yeon Lim, E Seul Kim, Huu Thuy Trang Duong, Hong Kee Kim, Sohyun Kim, Jung-Eun Kim, Doo Sung Lee, Jaeyun Kim, Min Sang Lee*, Yong Taik Lim* and Ji Hoon Jeong*, “Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles”, ACS Nano, 2018 (in press). (IF=13.709)

Young-Woock Noh, Sun-Young Kim, Jung-Eun Kim, Sohyun Kim, Jooyeon Ryu, Eunji Lee, Soong Ho Um and Yong Taik Lim,*, “Multifaceted Immunomodulatory Nanoliposomes Reshaping Tumors into Vaccines for Enhanced Cancer Immunotherapy”, Advanced Functional Materials, 8, 1605398 (2017). (IF=13.325)

Sun-Young Kim, Young-Woock Noh, Tae Heung Kang, Jung-Eun Kim, Sohyun Kim, Soong Ho Um, Doo-Byoung Oh, Yeong-Min Park, and Yong Taik Lim*, “Synthetic vaccine nanoparticles target to lymph node triggering enhanced innate and adaptive antitumor immunity”, Biomaterials, 130, 56-66 (2017). (IF=8.402)

Sun-Young Kim, Hathaichanok Phuengkham, Young-Woock Noh, Hong-Guen Lee, Soong Ho Um, and Yong Taik Lim* “Immune Complexes Mimicking Synthetic Vaccine Nanoparticles for Enhanced Migration and Cross-Presentation of Dendritic Cells”, Advanced Functional Materials, 26, 8072-8082 (2016). (IF=13.325)

Sun-Young Kim, Min Beom Heo, Geum-Sook Hwang, Youngae Jung, Do Yeol Choi, Yeong-Min Park,* and Yong Taik Lim* ” Multivalent Polymer Nanocomplex Targeting Endosomal Receptor of Immune Cells for Enhanced Antitumor and Systemic Memory Response”, Angewandte Chemie International Edition, 54(28), 8139-43 (2015). (IF=11.709)

Min Beom Heo and Yong Taik Lim* “Programmed Nanoparticles for Combined Immunomodulation, Antigen Presentation and Tracking of Immunotherapeutic Cells” Biomaterials, 35, 590-600 (2014). (IF=8.402)

Anushree Seth, Min Beom Heo, Yong Taik Lim*. “Poly (γ-glutamic acid) based combination of water-insoluble paclitaxel and TLR7 agonist for chemo-immunotherapy”. Biomaterials, 35, 7992-8001 (2014). (IF=8.402)

Young-Woock Noh, Ji Hyun Hong, Sangmu Shim, Hye Sun Park, Eun Kyoung Ryu, Jung Hwan Hwang, Cheol Ho Lee, Seong Hun Cho, Moon-Hee Sung, Haryoung Poo* and Yong Taik Lim* “Polymer Nanomicelles for Efficient Mucus Delivery and Antigen-specific High Mucosal Immunity”, Angewandte Chemie International Edition, 52, 7684-7689 (2013) (selected as VIP paper) (IF=13.734)

Kim J. H., Noh Y. W., Heo M. B., Cho M. Y. and Lim Y. T.* “Multifunctional hybrid nanoconjugates for efficient in vivo delivery of immunomodulating biomolecules and enhanced antitumor immunity”, Angewandte Chemie International Edition, 51(38), 9670-9673 (2012) (IF=13.455)

Noh Y. W., Kong S. H., Choi D. Y., Park H. S., Yang H. K., Lee H. J., Kim H. C., Kang K. W., Sung M. H. and Lim Y. T.* “Near-infrared emitting polymer nanogels for efficient sentinel lymph node mapping”, ACS Nano, 6(9), 7820-7831 (2012) (IF=11.421). (IF=13.709)

Hyun Min Kim, Hyunseung Lee, Kwan Soo Hong, Mi Young Cho, Moon-Hee Sung, Haryoung Poo, and Yong Taik Lim*, “Synthesis and High Performance of Magnetofluorescent Polyelectrolyte Nanocomposites as MR/Near-infrared Multimodal Cellular Imaging Nanoprobes”, ACS Nano 5(10), 8230-8240, 2011. (IF=13.709)

Professional Experience

2018.3– Present Professor, Sungkyunkwan University
2014.3– 2018.2 Tenured Associate Professor, Sungkyunkwan University
2009.9 – 2014.2 Associate Professor, Chungnam National University
2004.7 – 2009.8 Senior Scientist, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
2003.3 – 2004. 6. Senior Scientist, Electronics and Telecommunications Research Institute (ETRI)
2002.3 – 2003. 2. Post-Doctoral Research Fellow, Harvard Medical School
2002.9 2003. 2. Visiting Scientist, Massachusetts Institute of Technology (MIT)
1998.3 2002. 2. Research Assistant, Korea Advanced Institute of Science and Technology (KAIST)